By Christoph Stein, Christoph Stein

This quantity makes an attempt to summarize the present nation of information on mechanisms underlying a few of the results of analgesics, their facet impact profiles, and their symptoms and contraindications in scientific use. It additionally offers insights into present efforts to find novel mechanisms underlying the iteration of alternative different types of discomfort and the ensuing improvement of recent modulating compounds.

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In: Merskey H, Loeser JD, Dubner R (eds) The paths of pain 1975–2005. IASP Press, Seattle, pp 117–130 Palacek J, Dougherty PM, Kim SH, Paleckova V, Lekan V, Chung JM, Carlton SM, Willis WD (1992a) Responses of spinothalamic tract neurons to mechanical and thermal stimuli in an experimental model of peripheral neuropathy in primates. J Neurophysiol 68:1951–1966 Palacek J, Paleckova V, Dougherty PM, Carlton SM, Willis WS (1992b) Responses of spinothalamic tract cells to mechanical and thermal stimulation of skin in rats with experimental peripheral neuropathy.

Pain 81:57–65 Heppelmann B, Pawlak M (1999) Peripheral application of cyclo-somatostatin, a somatostatin antagonist, increases the mechanosensitivity of the knee joint afferents. Neurosci Lett 259:62–64 Peripheral and Central Mechanisms of Pain Generation 25 Hong S, Wiley JW (2005) Early painful diabetic neuropathy is associated with differential changes in the expression and function of vanilloid receptor 1. J Biol Chem 280:618–627 Hunt SP, Pini A, Evan G (1987) Induction of c-fos-like protein in spinal cord neurons following sensory stimulation.

Nausea and Vomiting . Cough Suppression . . Pupil Constriction . . Skeletal Muscle Rigidity . Gastrointestinal System . Histamine Release . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

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