By Chandan K. Sen, Lester Packer, Patrick A. Baeuerle
This quantity addresses oxidant-reduction or redox and antioxidant delicate molecular mechanisms and the way they're implicated in several affliction approaches. attainable innovations to pharmacologically and/or nutritionally manage such redox-sensitive molecular responses are emphasised. Key Features:* Reactive species as intracellular messengers* Redox legislation of mobile responses* medical implications of redox signaling and antioxidant treatment
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Extra resources for Antioxidant and Redox Regulation of Genes
These results revealed that not only were reactive oxygen species able to modulate the expression of mammalian gene expression, they also did so to a group of genes that are considered to be among the most important 2. Redox Regulation of Gene Expression Table I 25 Oxidant-Induced mRNAs in Mammalian Cells Gene Oxidant stress Reference c-fos, c-myc Xanthine/xanthine oxidase c-los, c-jun, egr-1, JE Hydrogen peroxide t-Butyl hydroperoxide Nitric oxide Multiple oxidants Hydrogen peroxide Hydrogen peroxide Hydrogen peroxide Menadione Crawford and Cerutti (1987) Nose et al.
38, 647-651. , Klotz, L. , and Sies, H. (1997). Toxic and signaling effects of chemically or photochemically generated singlet oxygen in biological systems. Biol. Chem. 378, 12591265. Camhi, S. , Sylvester, S. , and Choi, A. M. (1995). Induction of heme oxygenase-1 gene expression by lipopolysaccharide is mediated by AP-1 activation. Am. J. Respir. Cell Mol. Biol. 13, 387-398. Camhi, S. , Wiegand, G. , Chin, B. , and Choi, A. M. K. (1998). Transcriptional activation of the HO-1 gene by lipopolysaccharide is mediated by 5'distal enhancers: Role of reactive oxygen intermediates and AP-1.
1989). Using ultraviolet light as a stress agent, they discovered a number of genes that were induced by growth arrest and DNA damage. These so-called "'gadd'" genes were also found to be induced by oxidative stress. , 1992). Since identification of these genes, a growing number of nuclear-encoded mRNAs have also been reported as modulated by reactive oxygen species. , 1998). , 1996). Seven of these are induced and six are reduced. " Interestingly, one of these adapts, adapt15, is expressed coordinately with gadd45 and gadd153 and appears to be a member of the same gadd family.