By Chandan K. Sen, Lester Packer, Patrick A. Baeuerle

This quantity addresses oxidant-reduction or redox and antioxidant delicate molecular mechanisms and the way they're implicated in several affliction approaches. attainable innovations to pharmacologically and/or nutritionally manage such redox-sensitive molecular responses are emphasised. Key Features:* Reactive species as intracellular messengers* Redox legislation of mobile responses* medical implications of redox signaling and antioxidant treatment

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These results revealed that not only were reactive oxygen species able to modulate the expression of mammalian gene expression, they also did so to a group of genes that are considered to be among the most important 2. Redox Regulation of Gene Expression Table I 25 Oxidant-Induced mRNAs in Mammalian Cells Gene Oxidant stress Reference c-fos, c-myc Xanthine/xanthine oxidase c-los, c-jun, egr-1, JE Hydrogen peroxide t-Butyl hydroperoxide Nitric oxide Multiple oxidants Hydrogen peroxide Hydrogen peroxide Hydrogen peroxide Menadione Crawford and Cerutti (1987) Nose et al.

38, 647-651. , Klotz, L. , and Sies, H. (1997). Toxic and signaling effects of chemically or photochemically generated singlet oxygen in biological systems. Biol. Chem. 378, 12591265. Camhi, S. , Sylvester, S. , and Choi, A. M. (1995). Induction of heme oxygenase-1 gene expression by lipopolysaccharide is mediated by AP-1 activation. Am. J. Respir. Cell Mol. Biol. 13, 387-398. Camhi, S. , Wiegand, G. , Chin, B. , and Choi, A. M. K. (1998). Transcriptional activation of the HO-1 gene by lipopolysaccharide is mediated by 5'distal enhancers: Role of reactive oxygen intermediates and AP-1.

1989). Using ultraviolet light as a stress agent, they discovered a number of genes that were induced by growth arrest and DNA damage. These so-called "'gadd'" genes were also found to be induced by oxidative stress. , 1992). Since identification of these genes, a growing number of nuclear-encoded mRNAs have also been reported as modulated by reactive oxygen species. , 1998). , 1996). Seven of these are induced and six are reduced. " Interestingly, one of these adapts, adapt15, is expressed coordinately with gadd45 and gadd153 and appears to be a member of the same gadd family.

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