By Cyril Fisher (auth.)
Soft tissue tumors are a wide and heterogeneous workforce of tumors and pseudotumors with a spectrum of habit from benign to frankly malignant. This Atlas of sentimental Tissue Tumor Pathology offers an outline of reactive, pseudoneoplastic, benign and intermediate neoplasms, sarcomas and comparable stipulations coming up in subcutaneous and deep smooth tissues. Emphasis is put on microscopic appearances with correlation with gross diagnostic findings the place correct. additionally, the immunohistochemical and molecular genetic positive aspects of the key delicate tissue tumor subtypes are awarded. This compendium of sentimental tissue tumors illustrates nearly all of illnesses you will definitely come upon in surgical pathology.
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42 Ischemic fasciitis. This lesion (also termed atypical decubital fibroplasia) appears at pressure areas in immobilized patients but also in otherwise healthy individuals. There is infarction of fat with adjacent capillary proliferation and scattered spindle or stellate cells with enlarged hyperchromatic nuclei. The overlying skin is intact, unlike in the decubitus ulcer Fig. 44 Myofibroma. Primarily found in infants, this lesion is composed of myofibroblasts that are actin positive but lack desmin and h-caldesmon.
Pleomorphism and necrosis are absent, but normal mitotic figures sometimes are seen. Mast cells are a typical feature Fig. 5 Mesenteric fibromatosis. 1 Intermediate Tumors 39 Fig. 6 Plantar fibromatosis. Plump epithelioid and spindle myofibroblasts are distributed in dense collagen. This is often a hypocellular lesion. Small multinucleated cells sometimes are seen in this variant Fig. 8 Lipofibromatosis. A component of small adipocytes sometimes termed microfat may be seen, especially at the junction of fat and cellular fibrous areas Fig.
Marino-Enriquez A, Wang WL, Roy A, Lopez-Terrada D, Lazar AJ, Fletcher CD, et al. Epithelioid inflammatory myofibroblastic sarcoma: an aggressive intra-abdominal variant of inflammatory myofibroblastic tumor with nuclear membrane or perinuclear ALK. Am J Surg Pathol. 2011;35:135–44. Meis-Kindblom JM, Kindblom LG. Acral myxoinflammatory fibroblastic sarcoma: a low-grade tumor of the hands and feet. Am J Surg Pathol. 1998;22:911–24. Meis-Kindblom JM, Kindblom LG, Enzinger FM. Sclerosing epithelioid fibrosarcoma.