By Barbara J. Bain, David M. Clark, Irvin A. Lampert, Bridget S. Wilkins
Written by way of one of many world's top haematologists, and 3 well known histopathologists, Bone Marrow Pathology offers a accomplished advisor to the analysis of bone marrow disorder. Now in its 3rd version, the textual content has been generally revised and rewritten to mirror the most recent advances within the box.
An super sensible, up to date textual content incorporating the hot WHO type of haematopoietic malignancies
A complete textual content written with nice precision and readability of style
Incorporates a brand new part 'Problems and Pitfalls' - a different part that would relief the operating pathologist confronted with a tricky situation
An very important textual content for the haematologist, histopathologist and haematopathologist with equivalent weight given to peripheral blood, aspirate, trephine biology and really good techniques
Extensively illustrated with a few of the photos being of paraffin-embedded sections
Combines all of the concepts now utilized to bone marrow prognosis, together with immunocytochemistry, movement cytometery, immunohistochemistry and the diagnostic function of cytogenetic and molecular genetic analysis
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Extra resources for Bone Marrow Pathology (3rd Edition)
33 Section of normal BM showing cells of all haemopoietic lineages including a normal megakaryocyte with ﬁnely granular cytoplasm. Parafﬁnembedded, Giemsa ×940. Histology Megakaryocytes are by far the largest of normal bone marrow cells, their size being related to their ploidy. They have plentiful cytoplasm and usually a lobulated nucleus. With a Giemsa stain, the demarcation of platelets within the cytoplasm is apparent. 34). They are found in a paratrabecular position only when haemopoiesis is abnormal.
Films of squashed bone marrow fragments should similarly be examined in a systematic manner. Reporting a bone marrow aspirate The report of a bone marrow aspirate should commence with the clinical details given to the haematologist and a record of the full blood count and peripheral blood ﬁlm appearances at the time of bone marrow aspiration. There should then be a statement as to the site of aspiration, the texture of the bone and the ease of aspiration. The aspirate report should include an assessment of overall cellularity, an M:E ratio and a description of each lineage.
Fig. 70 BM trephine biopsy specimen showing dysplastic bladder epithelium which has been embedded with the biopsy as a result of contamination during processing. H&E ×96. specimen. Sometimes the abnormal tissue which is inadvertently included is dysplastic or neoplastic. Examination of reticulin stains can be helpful if there is doubt as to whether or not abnormal tissue is an intrinsic part of the biopsy specimen. If foreign tissue has been transferred with a knife, it will not be present if repeat sections are cut.