By Barbara J. Bain, David M. Clark, Bridget S. Wilkins

Bone Marrow Pathology has been greatly revised to mirror the numerous advances that have happened within the program of cytogenetics and particularly, molecular genetics within the analysis, category and knowing of haematological issues. This finished publication not just offers info on all universal disorder entities, but in addition covers infrequent problems during which bone marrow exam turns out to be useful. it's designed as useful source with ‘Problems and Pitfalls’ sections all through to help laboratory diagnosis.This fourth edition:Incorporates the strategies of the 2008 WHO type of Tumours of Haematopoietic and Lymphoid TissuesCovers key diagnostic suggestions equivalent to stream cytometric immunophenotyping, immunohistochemistry and cytogenetic and molecular genetic analysisIncludes new diagnostic algorithms and precis boxesContains 550 color illustrations together with top of the range electronic photomicrographs Haematologists and histopathologists will locate this e-book a useful computing device reference whilst acting day-by-day blood and bone marrow investigations.

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Extra info for Bone Marrow Pathology, Fourth edition

Example text

Because cells of different lineages may not be released from the fragments into the trails to the same extent there may not be good correlation between differential counts on wedge-spread films and squash preparations. It is likely that counts on the latter are more valid. However, counts are usually performed on wedge-spread films and hence published reference ranges are based on such counts. It is customary and useful to determine the myeloid : erythroid (M : E) ratio of aspirated marrow since consideration of this value, together with an assessment of the overall cellularity, allows an assessment of whether erythropoiesis and granulopoiesis are reduced, normal or increased.

Guidelines, integrated reporting and audit Guidelines for best practice in performing, processing and reporting bone marrow aspirates and tre- phine biopsies have been published [57,58]. If sedation is employed, guidelines for safe practice should be followed [4]. Optimal practice dictates that, for haematological neoplasms, an integrated final report should be assembled. This should include the results of all tests performed on a bone marrow aspirate and trephine biopsy specimen, interpreted in the context of full clinical and haematological information.

60 BM trephine biopsy section from a patient with chronic lymphocytic leukaemia showing torsion artefact. Paraffin-embedded, H&E ×20. Fig. 61 BM trephine biopsy section showing nuclei which appear glassy and homogeneous as a consequence of fixation artefact. Paraffin-embedded, H&E ×100. by the use of strong decalcifying agents. Often it is impossible to give any reliable interpretation of a poorly fixed marrow. Another fixation-related problem is deposition of formalin pigment. Formalin pigment is blackish-brown and should be distinguished from haemosiderin, which is golden brown (Fig.

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