By Professor Dr. Davide Schiffer, Professor Dr. Maria Teresa Giordana, Dr. Alessandro Mauro, Dr. Riccardo Soffietti (auth.)
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Moreover, brain tumors preferentially express type II isoform, whereas type I is the predominant isoform in normal adult brain . A second epigenetic mechanism potentially involved in regulation of NFl expression is RNA editing, a post-transcriptional site-specific modification of mRNA. 1 Genetics and Molecular Biology 21 moral tissues than in cells from normal individuals . The modification induced by mRNA editing at position 2914 may be functionally important involving the protein domain essential for interaction with ras .
In patients harboring defective VHL genes, elongin is not negatively regulated by the VHL gene product, resulting in excessive elongation of transcription and a high transcript level of as yet unidentified target genes . This mechanism may be extremely important, as the regulation of several oncogenes, including c-myc, is exerted at the level of transcript elongation . Mutations of the p53 tumor suppressor gene are the most frequent genetic abnormalities in human cancer; in about half of all cancer cases, the two p53 alleles are mutated or deleted [1376, 1932].
H&E, x200 cessary in drawing conclusions . Furthermore, the difficulty in demonstrating mitoses, which are very sensitive to anoxia  and require particular fixation techniques for visualization, has to be taken into account. The fundamental fact remains that in the adult, outside the subependymallayer, mitoses are very rare . Evidence has been obtained by labeling cells using retroviral injection that immature, dividing cells remain in the adult white matter, do not express differentiation antigens, and do not migrate .