By Vinod B. Shidham MD, Barbara F. Atkinson MD
This new reference examines specimen processing of effusion fluids, detailing the stairs had to receive extra exact diagnoses whereas keeping off universal pitfalls. A methodical, algorithmic method of the assessment and interpretation of specimens allows you to determine a definitive prognosis in those frequently tricky instances. ordinary good points - mixed with vast tables and algorithms - facilitate ease of interpretation, and highlighted info makes the main crucial recommendations effortless to reference quickly.
* keep away from strength mistakes in analysis with a whole bankruptcy that provides professional methods to specimen assortment and processing.
* Arrive at extra exact diagnoses due to step by step algorithms plus thousands of illustrations - together with a number of photos for every phenomenon representing a extensive diversity of stains and magnifications.
* in attaining optimum diagnostic simple task via viewing correlations among Pap, Diff-Quick (Romanowsky), and immunocytochemical stain for all types of serous effusion.
* realize the variation in cellphone samples yielded after washing the serous hollow space with saline or balanced salt answer as opposed to effusion fluid.
* comprehend the benefits and downsides of Pap stains as opposed to Diff-Quick stains in FNA evaluations.
* stay modern with the most recent applied sciences corresponding to liquid established cytology (SurePathT) and ThinPrepT.
* simply practice rules to real-life perform through reviewing specified histories.
* quick find the assistance you wish with a color-coded bankruptcy system.
* specialise in an important issues with effortless highlighted packing containers.
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Additional resources for Cytopathologic Diagnosis of Serous Fluids
The individual cells at the periphery of mesothelial clusters show recogniz- able cytoplasmic features of mesothelial cells and the nuclei do not touch the cell borders of the cells along the periphery of the group. 13a). 13). All mesothelial cells, including scattered solitary reactive mesothelial cells, are seemingly of one type, although with a wide morphologic spectrum. 11). 2 Panorama of mesothelial cells (ascitic ﬂuid). Central to near central nuclei. 5). 2g,i,o,p,r,t,u,v,w). 5). 4 Mesothelial cells versus adenocarcinoma cells (ascitic ﬂuid).
8). 3). 7). 13 Metastatic adenocarcinoma with a two-cell population (ascitic ﬂuid). Blue arrow RM highlights reactive mesothelial cells (central nuclei, peripheral vacuolation, community borders of cell groups formed by cell membrane) and red arrow NC highlights adenocarcinoma cells (eccentric nuclei touching the cell membranes without any rim of cytoplasm between the nucleus and cell membrane; the community border of cell groups is formed by mostly nuclear contours). 14 The cell-in-cell pattern of neoplastic cells (metastatic mammary carcinoma, pleural ﬂuid).
Their presence is due to forcible detachment of the serosal membrane during operative incision or intraoperative lavages, or both. 8). 10) in effusions are likely to be the most important diagnostic pitfall. 4) associated with groups of reactive mesothelial cells in sheets in effusions are as follows: 1. 26 Hepatomegaly related to congestive heart failure, leading to peritoneal effusion with exfoliation of sheets of reactive mesothelial cells from the surface of the congested liver. 3. 4. 5. Ischemic conditions such as pulmonary infarction, ischemic colitis, and occlusion of mesenteric blood vessels frequently show reactive changes in the serosal membranes surrounding the ischemic areas.