By Lazaros C. Triarhou
This e-book is the fruits of fifteen years of study at the transplantation of dopaminergic neurons within the striatum of the weaver mouse (wv/wv), a neurological mutant characterized
by means of genetically-determined degeneration of midbrain dopamine neurons. This mutant constitutes the single to be had laboratory version with a prolonged illness that mimics Parkinson's disorder. Structural and practical elements of
intrastriatal mesencephalic neuron grafting into the weaver version are reviewed, together with histochemical correlates of graft survival and integration, numerical elements of donor phone survival, ultrastructural findings on
synaptogenesis, neurochemical indices of dopamine uptake and receptor binding, gene expression of structural and neurotransmitter-receptor similar molecules, degrees of striatal amino acid receptors, and behavioural results of
unilateral and bilateral neuronal transplantations.
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Additional resources for Dompaminergic Neuron Transplantation in the Weaver Mouse Model of Parkinson's Disease (Neuroscience Intelligence Unit)
Mutations affecting the central nervous system in the mouse. In: Schmitt FO, Bird SJ, Bloom FE, eds. Molecular Genetic Neuroscience. New York: Raven Press, 1982:389-400. 99. Goldowitz D, Mullen RJ. Granule cell as a site of gene action in the weaver mouse cerebellum: Evidence from heterozygous mutant chimeras. J Neurosci 1982; 2:1474-1485. 100. Goldowitz D. The weaver granuloprival phenotype is due to intrinsic action of the mutant locus in granule cells: Evidence from homozygous weaver chimeras.
In normal development, there is a transient multiple innervation of Purkinje cells by climbing fibers, which later regresses, reaching a monoinnervation in adulthood. 94-96 Hippocampal Morphology By studying the anatomy and histology of the hippocampus in one-to-two month old weaver homozygotes, Sekiguchi et al97 have documented pyramidal cell ectopia and alterations of the mossy fiber trajectories. The pyramidal cell layer of area CA3 frequently appears to be thicker than normal, with an apparent increase in cell-free spaces corresponding to neuropil; furthermore, the pyramidal cell layer seems to be subdivided into two or three layers.
2. Bankiewicz K, Mandel RJ, Sofroniew M. Trophism, transplantation, and animal models of Parkinson’s disease. Exp Neurol 1993; 124:140-149. 3. Brundin P, Duan W-M, Sauer H. Functional effects of mesencephalic dopamine neurons and adrenal chromaffin cells grafted to the rodent striatum. In: Dunnett SB, Björklund A, eds. Functional Neural Transplantation. New York: Raven Press, 1994:9-46. 4. Norman RM. Primary degeneration of the granular layer of the cerebellum: An unusual form of familial cerebellar atrophy occurring in early life.