By Jerome Engel, Timothy A. Pedley

This three-volume paintings is the main entire, present, and authoritative textual content and reference on epilepsy. the celebrated editorial crew has assembled a roster of greater than a hundred and fifty famous specialists to create a balanced, fluent textual content protecting all modern rules and matters within the evaluate and administration of seizure disorders.The 289 chapters of this paintings handle all points of epilepsy, from simple mechanisms on the subcellular point to scientific syndromes and psychiatric matters. insurance comprises cutting-edge details on neurogenetics, neuroimaging, new medicinal drugs out there, and new surgical strategies for the remedy of epilepsy. such a lot chapters are written via a couple of writer from assorted scientific facilities to make sure a balanced presentation and characterize a consensus.

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5 The question of the relationship between seizures and interictal neurologic or psychiatric findings still generates controversy, however, because it is often not possible to distinguish among the effects of epilepsy per se, cerebral disease, psychological and social factors, and toxicity from chronic use of antiepileptic drugs. Whether distinct behavioral traits or profiles are associated with temporal lobe or other forms of epilepsy remains a matter of debate. 4 findings observed in surgical and autopsy specimens of epileptogenic brain areas, never produced enduring interictal consequences, even subtle, for behavior, personality, and social functioning.

An important change that has occurred and accelerated in the last two decades has been the growing ability to carry out basic studies in humans. 2 techniques used to evaluate patients with intractable seizures for surgery, and the removal of brain tissue during surgical procedures now offer investigators opportunities to investigate basic physiologic, biochemical, and molecular phenomena in patients that could previously be studied only in experimental animal models of epilepsy. Similarly, modern brain imaging methods, such as functional magnetic resonance imaging (fMRI), magnetic resonance spectroscopy (MRS), positron emission tomography (PET), and single-photon emission computed tomography (SPECT), allow noninvasive study of basic biologic questions in the living, intact brain.

Axis 2: Seizure type—from the List of Epileptic Seizures. Localization within the brain and precipitating stimuli for reflex seizures should be specified when appropriate. Axis 3: Syndrome—from the List of Epilepsy Syndromes, with the understanding that a syndromic diagnosis may not always be possible. Axis 4: Etiology—from a Classification of Diseases Frequently Associated with Epileptic Seizures or Epilepsy Syndromes when possible, genetic defects, or specific pathologic substrates for symptomatic focal epilepsies.

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