By Richard A. Prayson

The Frozen part Library sequence offers concise, undemanding, web site particular handbooks which are good illustrated and spotlight the pitfalls, artifacts and differential prognosis matters that come up within the moved quickly frozen part situation. Frozen part Library: principal fearful procedure is a handy, consumer pleasant instruction manual to aid within the review of important fearful process similar frozen sections. delivering an invaluable reference, equipped round differential diagnoses, essentially via place within the vital fearful method, it is going to end up a worthwhile device for the working towards surgical pathologist either in group and in educational facilities in addition to pathology citizens and fellows in education while faced with Neuropathology frozen part. Richard A. Prayson, MD is on the division of Anatomic Pathology, Cleveland hospital, Cleveland, OH Karl M. Napekoski, MD is on the division of Anatomic Pathology, Cleveland sanatorium, Cleveland, OH

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Frozen Section Library: Central Nervous System

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The presence of an atypical lymphoid population raises the possibility of a lymphoproliferative process. Most cases of primary central nervous system lymphoma arise as parenchymal masses, frequently in the periventricular region; such lesions may have indistinct borders on imaging studies. Patients who are immunocompromised are prone to develop lymphoma. Patients with a history of an organ transplant may develop a posttransplant lymphoproliferative disorder, which may look histologically ­indistinguishable from lymphoma at frozen section.

A diagnosis of malignant spindled cell neoplasm at the time of frozen section is appropriate with a suggestion that it may represent a metastasis from the patient’s known laryngeal carcinoma. Cerebral Parenchymal Lesions: I. Metastatic Neoplasms 51 These are all high-grade neoplasms and may be marked by cells with high nuclear to cytoplasmic ratio, readily identifiable mitotic activity, and apoptosis. In some cases, particularly on a limited sample or extensively necrotic sample, immunohistochemistry may be needed to make the final diagnosis.

FLAG 3: GRANULOMATOUS INFLAMMATION The presence of granulomas at frozen section should raise concern about an infectious process, particularly when necrosis is present. Recommendation for microbiologic culturing should be made. The presence of granulomas should be documented in the frozen section report as well as the presence of any accompanying necrosis. 14). Although in most cases, fungal organisms are going to be best seen with special stains that are not available at the time of frozen section, one should nevertheless look for the evidence of hyphae.

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