By Laurence L. Brunton

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"The eleventh variation of Goodman & Gilman is still the main entire and authoritative unmarried resource at the pharmacology of gear. the 1st version was once released by means of Alfred Gilman and Louis Goodman in 1941. It quickly grew to become referred to as the bible of pharmacology and, even if editorship and bankruptcy authorships have replaced continually from version to version, this continues to be the optimum of pharmacology textbooks....The print model can be at the reference shelf and the electronic model at the desktop machine of all practising pharmacologists, pharmacists, and physicians."--Doody's evaluation Service

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Extra info for Goodman & Gilman´s The Pharmacological Basis of Therapeutics

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Nevertheless, for some patients, me-too drugs may have better efficacy or fewer side effects or promote compliance with the treatment regimen. For example, the me-too that can be taken but once a day and not more frequently is convenient and promotes compliance. Some "me-toos" add great value from a business and medical point of view. Atorvastatin was the seventh statin to be introduced to market; it subsequently became the best-selling drug in the world. Introduction of similar products in other industries is viewed as healthy competition.

Changes in protein binding due to disease states and drug-drug interactions are clinically relevant mainly for a small subset of so-called high-clearance drugs of narrow therapeutic index (described later) that are administered intravenously, such as lidocaine (Benet and Hoener, 2002). When changes in plasma protein binding occur in patients, unbound drug rapidly equilibrates throughout the body and only a transient significant change in unbound plasma concentration will occur. , anti-arrhythmics) will show a measureable effect.

Both local and systemic reactions to allergens may occur subsequent to inhalation. Topical Application Mucous Membranes Drugs are applied to the mucous membranes of the conjunctiva, nasopharynx, oropharynx, vagina, colon, urethra, and urinary bladder primarily for their local effects. Occasionally, as in the application of synthetic anti-diuretic hormone to the nasal mucosa, systemic absorption is the goal. Absorption through mucous membranes occurs readily. In fact, local anesthetics applied for local effect sometimes may be absorbed so rapidly that they produce systemic toxicity.

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