By Isidoro Di Carlo

This ebook deals a whole assessment on non colorectal non neuroendocrine (NCRNNE) liver metastases and describes intimately the at present to be had remedies. every one bankruptcy specializes in the remedy of metastases from a selected basic malignancy and in addition presents priceless info on occurrence, traditional heritage and analysis. NCRNNE liver metastases are infrequent entities in comparison with colorectal and neuroendocrine metastases, for which the remedies are good codified. whereas extra guides have seemed at the subject lately, an in-depth learn has up to now been missing. moreover, such a lot released sequence are insufficiently similar as they include sufferers with NCRNNE hepatic metastases from quite a few fundamental malignancies and for this reason forget ameliorations in tumor habit, frequency of remoted hepatic metastases, reaction to neoadjuvant or adjuvant treatment and period among analysis of the first tumor and the liver metastases. This booklet, with its extra particular strategy, will serve not just as an up to date advisor to analysis and remedy but additionally as a reference on which to base destiny studies.

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Extra resources for Noncolorectal, Nonneuroendocrine Liver Metastases: Diagnosis and Current Therapies

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Bipat S, Leewen MS, Comans EFI et al (2005) Colorectal liver metastases: CT, MR imaging, and PET for diagnosis-meta-analysis. Radiology 237:123–131 16. Kinkel K, Lu Y, Both M et al (2002) Detection of hepatic metastases from cancers of the gastrointestinal tract by using noninvasive imaging methods (US, CT, MR imaging, PET): a meta-analysis. Radiology 224:748–756 17. Ward J, Robinson PJ, Guthrie JA et al (2005) Liver metastases in candidates for hepatic resection: comparison of helical CT and gadolinium- and SPIO-enhanced MR imaging.

The pathophysiology of Stauffer’s syndrome is unclear. In most patients the syndrome resolves after nephrectomy and may recur with recurrence of the cancer suggesting involvement of a humoral substance [13]. Anyway in case of increased alkaline phosphatase, increased transaminases, and prolonged prothrombin time, the first step must be the exclusion of liver metastases. 3 Diagnosis and Staging In patient with kidney cancer staging is a fundamental step to determine both prognosis and therapeutical approach.

Sakaguchi et al. in 1992 demonstrated the feasibility of simultaneous liver resection and nephrectomy for a large RCC with caval thrombus [24]. The main problem to deal with during combined procedure is that liver resection and nephrectomy need conflicting hemodynamic techniques: during nephrectomy, a normovolemic or hypervolemic state is preferred to supply the contralateral kidney with adequate volume, therefore maximizing renal plasma flow to the remnant kidney. By contrast, relative hypovolemia is desired during hepatic resection (low central venous pressure technique) to limit blood loss during parenchymal transection phase of the operation.

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