By Professor Dr. Dres. h. c. Wilhelm Doerr (auth.)

Die Arbeit vermittelt einen Oberblick }ber die geistige Si- tuation der Pathologie an der Universit{t Heidelberg von 1945-1983, der wissenchaftlichen Arbeiten des "Heidelberger Kreises" und die Einbindung desDepartmentsystems der Hei- delberger Pathologie in die mitteleurop{ische Entwicklung der Krankheitsforschung.

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Jacquemin E: Role of multidrug resistance 3 deficiency in pediatric and adult liver disease: one gene for three diseases. Semin Liver Dis. 21(4):551-62, 2001 6. Thompson R et al: BSEP: function and role in progressive familial intrahepatic cholestasis. Semin Liver Dis. 21(4):545-50, 2001 7. van Mil SW et al: FIC1 disease: a spectrum of intrahepatic cholestatic disorders. Semin Liver Dis. 21(4):535-44, 2001 8. Alonso EM et al: Histologic pathology of the liver in progressive familial intrahepatic cholestasis.

I(1):27 Image Gallery Microscopic Features of PFIC2 (BSEP Deficiency) (Left) Biopsy in an infant with PFIC2 (BSEP deficiency) shows nodule formation and portal inflammation. (Right) Higher magnification of a biopsy in an infant with PFIC2 (BSEP deficiency) shows perinodular inflammation and bile pigment within hepatocytes . 53 Diagnostic Pathology: Hepatobiliary and Pancreatic (Left) Biopsy in an infant with PFIC2 (BSEP deficiency) shows bile plugs within canaliculi , inflammation, and extramedullary hematopoiesis .

Jedlitschky G et al: Structure and function of the MRP2 (ABCC2) protein and its role in drug disposition. Expert Opin Drug Metab Toxicol. 2(3):351-66, 2006 3. Lee JH et al: Neonatal Dubin-Johnson syndrome: long-term follow-up and MRP2 mutations study. Pediatr Res. 59(4 Pt 1):584-9, 2006 4. Rastogi A et al: Dubin-Johnson syndrome—a clinicopathologic study of twenty cases. Indian J Pathol Microbiol. 49(4):500-4, 2006 5. Sobaniec-Lotowska ME et al: Ultrastructure of Kupffer cells and hepatocytes in the Dubin-Johnson syndrome: a case report.

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